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FabRICATOR® Z Immobilized

Immobilized enzyme for below hinge digestion of mouse IgG2a and IgG3 in spin columns

(Genovis)

FabRICATOR Z (IdeZ) is a cysteine protease that digests mouse IgG2a and IgG3 at a specific site below the hinge, generating a homogenous pool of F(ab’)2 and Fc fragments after a two-hour incubation.

The FabRICATOR Z Immobilized spin columns contain the FabRICATOR Z enzyme covalently coupled to agarose beads, for digestion of mouse IgG2a and IgG3 without contaminating the final preparation with enzyme.

The Microspin columns are available for digestion of 2 x 0.5 mg, 5 x 0.5 mg, or 10 x 0.5 mg mouse IgG2a or IgG3.

Why FabRICATOR® Z Immobilized?
  • Easy-to-use spin columns
  • Increased enzyme-to-substrate ratio for improved digestion efficiency
  • No enzyme in the final sample